All documents in ORBi are protected by a user license. O pen R epository and Bi bliography. You are here: ORBi Detailled reference. In case of anti-D immunisation, the paternal Rh phenotype, when known, provides useful information regarding the probability for the fetus to have inherited the D antigen and thereby to be exposed to the risk of HDFN. The antibody titre, which is predictive of possible in vivo haemolysis, must be interpreted in the light of the previous obstetric history, and can lead to the decision of invasive amniocentesis.
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In most industrialized countries, a systematic prevention policy is applied with immunoglobulin injections for the above cited situations and during the third trimester to cover the risk of spontaneous occult fetomaternal hemorrhage occurring at the end of pregnancy. Compare the efficacy of two strategies for antenatal prevention. Material and methods. Review of the literature of published comparative studies.
Eleven studies were retained two randomized trials, seven comparative studies, one before-after study, one population-based study including more than 30, treated patients. Globally, immunization rate was to the order of 1. Comparative analyses have reported significant odds ratios of 0. Despite the heterogeneous nature of the published studies, available data are in favor of systematic prevention: either with a g dose at 28GW or g at 28GW and 34GW complementary to the postnatal prevention.
Few data are available on the real perinatal benefit of systematic prevention. Keywords: Rhesus allo-immunization , Systematic prevention , Targeted prevention. Click here to see the Library ]. J Gynecol Obstet Biol Reprod sous presse. Current status of immunoprophylaxis with anti-D immunoglobulin. Vox Sanguinis ; 85 : Maternal-fetal Medicine Committee, Genetics Committee. Prevention of Rh alloimmunization. J Obstet Gynaecol Can ; 25 : Causes and clinical consequences of Rhesus D haemolytic disease of the newborn: a study of a Scottish population, Br J Obstet Gynaecol ; : Management of large feto-maternal haemorrhages in D negatives women.
Blood Matters ; 13 : Prevention of hemolytic disease of the fetus and the newborn: it is necessary to act. J Gynecol Obstet Biol Reprod ; 29 : A review of the clinical effectiveness of routine antenatal anti-D prophylaxis for rhesus-negative women who are pregnant. BJOG ; : Indicators of quality of antenatal care: a pilot study.
Click here to see the Library ] , [ 14 Bowman JM. The prevention of Rh immunization. Transfus Med Rev ; 2 : The scientific basis of antenatal prophylaxis. Br J Obstet Gynaecol ; Suppl 18 : Massive fetomaternal hemorrhage: Manitoba experience. Obstet Gynecol ; 83 : Massive fetomaternal hemorrhage. Int J Gynaecol Obstet ; 50 : The pathogenesis and prevention of Rh immunization. Can Med Assoc J ; 97 : Rh isoimmunization during pregnancy: antenatal prophylaxis.
Can Med Assoc J ; : Prevention of Rh D alloimmunization. Number 4, May replaces educational bulletin Number , October Clinical management guidelines for obstetrician-gynecologists. American College of Obstetrics and Gynecology.
Int J Gynaecol Obstet ; 66 : Recommendations for the use of anti-D immunoglobulin for Rh prophylaxis. Transfus Med ; 9 : A review of the clinical effectiveness and cost-effectiveness of routine anti-D prophylaxis for pregnant women who are rhesus-negative. Health Technol Assess ; 7 : iii Routine antenatal Rhesus D immunoglobulin prophylaxis: the results of a prospective 10 year study.
Rh hemolytic disease of the newborn--the disease eradicated by immunology. Clin Obstet Gynecol ; 20 : Anti-D administration after childbirth for preventing Rhesus alloimmunisation. Ante-partum administration of preventive treatment of Rh-D immunization in rhesus-negative women. Parallel evaluation of transplacental passage of fetal blood cells.
Results of a multicenter study carried out in the Paris region. J Gynecol Obstet Biol Reprod ; 16 : Multicentre trial of antepartum low-dose anti-D immunoglobulin. Transfus Med ; 5 : Failures of intravenous Rh immune globulin prophylaxis: an analysis of the reasons for such failures.
Transfus Med Rev ; 1 : Click here to see the Library ] , [ 31 Trolle B. Prenatal Rh-immune prophylaxis with micrograms immune globulin anti-D in the 28th week of pregnancy.
Acta Obstet Gynecol Scand ; 68 : Antenatal prophylaxis of Rh immunization with micrograms anti-D. Acta Obstet Gynecol Scand ; : The Yorkshire antenatal anti-D immunoglobulin trial in primigravidae. Lancet ; 2 : Rate of RhD sensitisation before and after implementation of a community based antenatal prophylaxis programme. BMJ ; : Anti-D administration in pregnancy for preventing rhesus alloimmunisation.
Long-term neurodevelopmental outcome after intrauterine transfusion for the treatment of fetal hemolytic disease. Am J Obstet Gynecol ; : Branger, N. Journal page Archives Sommaire. Ravinet, B. Article Article Outline.
Access to the text HTML. Access to the PDF text If you experience reading problems with Firefox, please follow this procedure. Recommend this article. Save as favorites. Free Article! Outline Masquer le plan. Top of the page - Article Outline. Brossard Y. Branger B, Winer N. De Silva M. Brossard Y, Poissonnier MH. Mervant C. Vause S, Maresh M. Bowman JM. Urbaniak SJ. Zipursky A, Israels LG. ACOG practice bulletin. Zipursky A. Crowther CA, Middleton P. Lee D, Rawlinson VI. Trolle B.
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No 133-Prévention de l'allo-immunisation fœto-maternelle Rh.
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In most industrialized countries, a systematic prevention policy is applied with immunoglobulin injections for the above cited situations and during the third trimester to cover the risk of spontaneous occult fetomaternal hemorrhage occurring at the end of pregnancy. Compare the efficacy of two strategies for antenatal prevention. Material and methods. Review of the literature of published comparative studies. Eleven studies were retained two randomized trials, seven comparative studies, one before-after study, one population-based study including more than 30, treated patients. Globally, immunization rate was to the order of 1.
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