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GEO help: Mouse over screen elements for information. Not logged in Login. Series GSE Adaptaquin is an inhibitor of oxygen-sensing prolyl-hydroxylase domain enzymes that abrogates ATF4-dependent death and improves outcomes from brain hemorrhage.
Mus musculus. Disability or death secondary to intracerebral hemorrhage ICH is attributed to blood lysis, liberation of iron and generation of oxidative stress.
Iron chelators bind free iron and prevent neuronal death induced by oxidative stress and disability due to ICH, but the mechanisms remain unclear. Here we show that the hypoxia-inducible factor prolylhydroxylase HIF PHD family of iron-dependent oxygen sensors is an effector of iron chelation in abrogating ICH-induced death. A low molecular weight, hydroxyquinoline inhibitor of the HIF PHDs, which we call adaptaquin, reduces neuronal death and behavioral deficits following ICH in distinct rodent models.
Unexpectedly, adaptaquin protects from oxidative death by suppressing ATF4- dependent prodeath gene expression rather than by activating a HIF-dependent prosurvival pathway. SOFT formatted family file s.
MINiML formatted family file s. Series Matrix File s.
GEO help: Mouse over screen elements for information. Not logged in Login. Series GSE Adaptaquin is an inhibitor of oxygen-sensing prolyl-hydroxylase domain enzymes that abrogates ATF4-dependent death and improves outcomes from brain hemorrhage. Mus musculus.
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Photo added by Garver Graver. He is seen by many as an ideological father of Canadian nationalism. In , he became mayor of the town of Montebello, Quebec, at age In , he was elected to the House of Commons as an independent Liberal for Labelle County, but resigned in to protest against the sending of Canadian troops to the Second Boer War. He was re-elected soon after his resignation. He argued that Prime Minister Wilfrid Laurier was un vendu "a sell-out" to British imperialism and its supporters in Canada.
Return to footnote 3 referrer Footnote 4 Age Refers to the age at last birthday before bourssa reference date, that is, before May 10, Statistics Canada, Census of Population. Bourassa Federal electoral district, Representation OrderQuebec. About the Census Profile Geographic levels Help with searching About the data Incompletely enumerated Indian reserves and Indian settlements Random rounding Area and data suppression About federal electoral bourass Representation Order. He died from cancer gourassa at the age of Some of the data sets are large and require special consideration during processing in order to successfully make use of them. Yogul See all ReviverSoft resources. This application belongs to the Java Development Kit, wherein it is known as a set of tools that is used for Java application development. The Java Runtime Environment also features a Java virtual machine and this is the feature that enables Java applications to run on a certain operating system.