GLYCEMIC DURABILITY OF ROSIGLITAZONE METFORMIN OR GLYBURIDE MONOTHERAPY PDF

The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term glycemic control in type 2 diabetes is not known. We evaluated rosiglitazone, metformin, and glyburide as initial treatment for recently diagnosed type 2 diabetes in a double-blind, randomized, controlled clinical trial involving patients. The patients were treated for a median of 4. The primary outcome was the time to monotherapy failure, which was defined as a confirmed level of fasting plasma glucose of more than mg per deciliter

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Read article at publisher's site DOI : Prospective Diabetes Study Group. Yki-Jarvinen H. Nat Commun , 10 1 , 20 Dec Pharmacoecon Open , 3 4 , 01 Dec Genes Nutr , , 27 Nov Lebovitz HE.

Curr Diab Rep , 19 12 , 27 Nov PLoS One , 14 11 :e, 08 Nov This data has been text mined from the article, or deposited into data resources. To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Am J Med , 4 , 01 Feb Cited by 54 articles PMID: Scheen AJ. Rev Med Liege , 62 1 , 01 Jan Cited by 3 articles PMID: Diabetes Care , 33 1 , 06 Oct Clin Ther , 25 12 , 01 Dec Cited by 62 articles PMID: Papoushek C.

J Obstet Gynaecol Can , 25 10 , 01 Oct Coronavirus: Find the latest articles and preprints. Europe PMC requires Javascript to function effectively. Recent Activity. Recent history Saved searches. Abstract Read article for free, via Unpaywall a legal, open copy of the full text. Kahn SE 1 ,. Haffner SM ,. Heise MA ,. Herman WH ,. Holman RR ,. Jones NP ,. Kravitz BG ,. Lachin JM ,. O'Neill MC ,. Bernard Zinman Search articles by 'Bernard Zinman'.

Zinman B ,. Giancarlo Viberti Search articles by 'Giancarlo Viberti'. Viberti G ,. Affiliations 1 author 1. A comment on this article appears in " ADOPT: lessons from comparison of glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. A comment on this article appears in " Glycemic durability of monotherapy for diabetes. Show all 9. Share this article Share with email Share with twitter Share with linkedin Share with facebook.

We evaluated rosiglitazone, metformin, and glyburide as initial treatment for recently diagnosed type 2 diabetes in a double-blind, randomized, controlled clinical trial involving patients. The patients were treated for a median of 4. The primary outcome was the time to monotherapy failure, which was defined as a confirmed level of fasting plasma glucose of more than mg per deciliter Prespecified secondary outcomes were levels of fasting plasma glucose and glycated hemoglobin, insulin sensitivity, and beta-cell function.

The difference in the durability of the treatment effect was greater between rosiglitazone and glyburide than between rosiglitazone and metformin. The potential risks and benefits, the profile of adverse events, and the costs of these three drugs should all be considered to help inform the choice of pharmacotherapy for patients with type 2 diabetes. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study.

Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies UKPDS Glycemic control from to among U. Sulfonylurea inadequacy: efficacy of addition of insulin over 6 years in patients with type 2 diabetes in the U.

Yki-Jarvinen H N. Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women. Prevention of type 2 diabetes with troglitazone in the Diabetes Prevention Program. Show 10 more references 10 of Smart citations by scite. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.

Explore citation contexts and check if this article has been supported or contradicted. Thiazolidinediones: the Forgotten Diabetes Medications. Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals.

Clinical Trials 1 citation ClinicalTrials. Rosiglitazone decreases C-reactive protein to a greater extent relative to glyburide and metformin over 4 years despite greater weight gain: observations from a Diabetes Outcome Progression Trial ADOPT.

Metformin hydrochloride in the treatment of type 2 diabetes mellitus: a clinical review with a focus on dual therapy. The "glitazones": rosiglitazone and pioglitazone. This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy. I agree, dismiss this banner. Wicket Ajax Debug Window drag me here.

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Glycemic Durability of Rosiglitazone, Metformin, or Glyburide Monotherapy

Background: The efficacy of thiazolidinediones, as compared with other oral glucose-lowering medications, in maintaining long-term glycemic control in type 2 diabetes is not known. Methods: We evaluated rosiglitazone, metformin, and glyburide as initial treatment for recently diagnosed type 2 diabetes in a double-blind, randomized, controlled clinical trial involving patients. The patients were treated for a median of 4. The primary outcome was the time to monotherapy failure, which was defined as a confirmed level of fasting plasma glucose of more than mg per deciliter Prespecified secondary outcomes were levels of fasting plasma glucose and glycated hemoglobin, insulin sensitivity, and beta-cell function. The difference in the durability of the treatment effect was greater between rosiglitazone and glyburide than between rosiglitazone and metformin.

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Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy.

Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Read article at publisher's site DOI : Prospective Diabetes Study Group. Yki-Jarvinen H. Nat Commun , 10 1 , 20 Dec

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Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Kahn and Steven M. Haffner and Mark A. Holman and Nigel P. Jones and Barbara G.

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